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KMID : 1189420110240010036
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2011 Volume.24 No. 1 p.36 ~ p.44
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Effects of Propolis on the Ovalbumin-Induced Allergic Asthma in Mice
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Byun Ji-Hwan
Jo Eun-Hee
Mendgerel
Park Min-Cheol
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Abstract
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Objective :Propolis (PP) has been used in oriental medicine. PP has various biological activities. However, its immunoregulatory and anti-inflammatory activities have not been well studied. In this study, I investigated these activities of PP by using ovalbumin-induced allergic asthma in mice.
Methods:To examine the effect of PP on allergic asthma, mice were sensitized with 100㎍ of OVA and 1mg of aluminum potasssium sulfate (Alum; Sigma) intraperitoneally on day 0 and 7. On day 14, mice were challenged on consecutive 3 days with 5% OVA and AHR was assessed 24 hours after the last challenge. To examine severity of AHR, I examined the population of eosinophiles and T cells in spleen and lung and cytokine production in T cells. Futhermore, I examined histological changes during the OVA-induced allergic asthma.
Results and Conclusion:PP reduced the population of eosinophil and CD4+ T cells on the OVA-induced AHR mice model. PP also inhibited IL-4 production but increased INF-g production in T cells. These results suggest that PP may be beneficial material for allergic asthma.
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KEYWORD
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propolis, asthma, ovalbumin, CD4+ T cell, cytokine
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